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Abstract

A comparative study of the determination of iron composition in some commercial iron tablets/capsule using spectrophotometric method. Spectrophotometric method is based on the formation of complex iron compound- ferrous tris-o-phenanthroline complex by boiling with hydroxylamine hydrochloride and subsequent addition with 1, 10 - phenanthroline at pH ~ 3±0.2 and the absorbance of this colored solution is measured with a spectrophotometer at 508nm. A calibration curve was found to be linear up to the concentration range of 0.0004 mg/ml to 0.0040 mg/ml. Total four pharmaceutical samples from different pharmaceutical companies were analyzed and results were compared with WHO iron intake for human consumption requirement. The study showed that the total iron content in pharmaceutical samples were 46.41 mg, 28.93 mg, 18.86 mg and 29.54 per 1g of the samples. These values are in good agreement with WHO standard and pharmaceutical range.

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Keywords

Phenanthroline, Spectrophotometric Method, Iron Tablets, Iron Capsule.